Title: A Novel, Efficient, Diastereo- and Enantioselective Mukaiyama Aldol-Based Synthesis of a Vinyl Cyclopentanone Core Derivative of Viridenomycin

Journal: Organic Letters, 2007, 9 (26), 5565-5568.

Authors: Andrei S. Batsanov, Jonathan P. Knowles, Andrew P. Lightfoot, Graham Maw, Carl Thirsk, Steven J. R. Twiddle, and Andrew Whiting*

DOI: 10.1021/ol7025262

Abstract: A strategy has been developed for a rapid seven-step construction of a chiral, nonracemic vinyl cyclopentanone building block as part of a synthetic approach to viridenomycin, using a diastereo- and enantioselective Mukaiyama aldol and intramolecular Knoevenagel condensation as key steps.